12.Anti-tTG blood test shows 1 in 80 celiac in population Moderated discussion and help for gluten free, coeliac, celiac, wheat allergies or intolerance, Cookery and recipes part 2

Re: Anti-tTG blood test shows 1 in 80 celiac in population: from on 2002-11-18

I tried the web site technapoli etc. but it was in Italian and I was unable to get the research article. How can I get a copy of the research. I have Celiac Disease and recovered from RA, Sjogren's and Lupus after accidental diagnosis. I also have both of the main genes for Celiac. I need information to try to get data to present to my grandchildren's doctor as they both show show signs of the diease and my daughter is totally resistant to having them tested. They are eight and thirteen years old. Could you tell me the major sites for research in the European Journals on Celiac.

Also do you know of any medical journals linking pancreatic disease and celiac?
Thank you so much for your help. My fax number is 310-393-3400 and my phone is 310-393-1353 should you wish to contact me. Again, Thank you. Marlene

Re Anti-tTG blood test shows 1 in 80 celiac in population: from Arline Chambers on 2005-05-10

Simple question - what is the range of test scores fo Ttg? What is the "normal" range for Ttg? I have a number "88". What does it really mean? Many thanks.

Re Anti-tTG blood test shows 1 in 80 celiac in population: from Mari on 2005-06-22

do you have to do a gluten challenge before having the Anti-Tissue Transglutaminase (tTG) IgA test?

Re Anti-tTG blood test shows 1 in 80 celiac in population: from Peter on 2005-06-23

The following paper highlights the need for a gluten challenge. Note the results for group 2 - children on a gluten-free diet, compared with the results for group 3 - children on a gluten challenge. This very sensitive test detected less than half of known celiacs on a gluten-free diet without a challenge.

Peter


Title Radioimmunoassay to detect antitransglutaminase autoantibodies is the most sensitive and specific screening method for celiac disease.
Source Am J Gastroenterol (The American journal of gastroenterology.) 2001 May; 96(5) 1536-40
Additional Info United States
Standard No ISSN 0002-9270; NLM Unique Journal Identifier 0421030
Language English
Abstract OBJECTIVE The aim of this study was to establish the most sensitive and specific screening method for celiac disease. We tested three methods based on different principles, which all detect autoantibodies against the same antigen (tissue transglutaminase). METHODS Sixty-two celiac children at the first biopsy (group 1), 78 celiac children on a gluten-free diet (group 2), 14 celiac children on a gluten-challenge (group 3), and 56 controls with a normal duodenal mucosa (group 4) were studied. The methods used were 1) radioimmunoprecipitation assay using recombinant tissue transglutaminase (RIA); 2) commercial enzyme immunoassay using guinea pig tissue transglutaminase (ELISA); and 3) indirect immunofluorescence method for detection of antiendomysium antibodies (IF-EMA). RESULTS RIA antitransglutaminase autoantibodies were detected in 100\% of group 1, 43.6\% of group 2, 100\% of group 3, and none of the control subjects. ELISA antitransglutaminase autoantibodies were detected in 90.3\% of group 1, 9\% of group 2, 78.6\% of group 3, and in none of the control subjects. IF-EMA were detected in 95.2\% of group 1, 11.5\% of group 2, 92.3\% of group 3, and 1.8\% of the controls. CONCLUSIONS Our results demonstrate a very high sensitivity and specificity of the RIA method to detect antitransglutaminase autoantibodies in comparison to ELISA and IF-EMA assays. We can explain this finding with the use of human recombinant antigen and the increased capacity of the RIA method to detect low titers of autoantibodies. If our data are confirmed by studies on larger series, tissue transglutaminase RIA could be proposed as the best screening method for celiac patients.

Re: Anti-tTG blood test shows 1 in 80 celiac in population: from mobo on 2008-04-22

If after blood tests one is allergic to cows milk, gluten, egg white, wheat, buck wheat, rice, rye flour and yeast, is one consider to be a celiac