117.celiac Moderated discussion and help for gluten free, coeliac, celiac, wheat allergies or intolerance, Cookery and recipes part 3

Re: Anti-tTG blood test shows 1 in 80 celiac in population: from on 2002-11-18

I tried the web site technapoli etc. but it was in Italian and I was unable to get the research article. How can I get a copy of the research. I have Celiac Disease and recovered from RA, Sjogren's and Lupus after accidental diagnosis. I also have both of the main genes for Celiac. I need information to try to get data to present to my grandchildren's doctor as they both show show signs of the diease and my daughter is totally resistant to having them tested. They are eight and thirteen years old. Could you tell me the major sites for research in the European Journals on Celiac.

Also do you know of any medical journals linking pancreatic disease and celiac?
Thank you so much for your help. My fax number is 310-393-3400 and my phone is 310-393-1353 should you wish to contact me. Again, Thank you. Marlene

Re: Immune System and Celiac: from on 2002-12-01

I think my immune system is quite strong, even though I am coeliac. I never get a flu even when everyone around me has it! Before coeliac disease was diagnosed, I used to get ill only in times in which I was particularly anaemic and physically weak.

Grazia

Re: DH as a celiac symptom: from on 2003-10-15

I have had many tests for ecxema including blood tests which showed negative for gluten. However, I saw a Kinesiologist who tested me positive for gluten intolerance. For 8 months I have been on a gluten free diet and have not felt so good for a long time, both bodily and my skin. I have also lost 3kg in weight which is a bonus. My skin is nearly always free from rashes (I am also allergic to formaldehyde which is difficult to remove from the house). I have been introduced to 'Dermatique' which is a natural skin care (creamss/lotions) which I have found to be very good (a bit expensive though

Re: celiac sprue and ulcerative colitis: from on 2004-03-23

I have just been diganosed with celiac sprue. One thing I have read about is that Maker's Mark Bourbon is supposed to be tolerated by those with sprue. Do you have any info on that.

Thank you for your time.

Mike Graham

Solution to Celiac - Oral Tolerance: from on 2004-04-06

br />
The source of the problem of Celiac Disease/gluten
intolerance is an overproduction of antibodies to gluten. Generally, celiacs are found to have high blood levels of the antibodies -Immunoglobin A and Immunoglobin G (Ig A & Ig G) to gluten. Some celiacs have low Ig A while
high Ig G is universal to all celiacs/gluten intolerant subjects. Therefore, it is the high Ig G
that needs to be addressed in solving this problem.

Has medical research found a mechanism that actually lowers Ig G which can be applied to autoimmune diseases such as celiac disease? The answer is Yes.


Production of antibodies is controlled by the T cells
which is part of the immune system. The helper T cells
program the immune system to increase antibody production; the suppressor T cell does the opposite
- it lowers production.

The condition or requirement for lowering antibody
levels is having the target antigen accepted by the
suppressor T cell.
This is where Oral Tolerance (O.T.)comes in -
a process that can access the suppressor cell.

In O.T., a peptide(part of protein) having similar antigenic determinants as gliadin(in gluten) is taken orally. Once it is processed by the suppressor T cell, the immune system is set in motion lowering blood levels of specific antibodies and will result
in a cure.

There are 3 activities involved in oral tolerance.
1. Secretion of transfer growth facter-b at the target site. This sends a signal to immune cells to back-off from attacking the small intestine.

2. Clonal Anergy means the immune cells may come within reach of the target organ but will not react.

3. Clonal deletion means the cells that are responsible for antibody production specific to gluten are deleted.

All the above will end autoimmune response and will fix celiac disease.

O.T. has been researched since the 70's and is safe.
Its mechanism has had clinical trials on animals and humans for autoimmune conditions such as uveitis, arthritis, and multiple sclerosis. There are also tests
on diabetes.

A better understanding of Oral Tolerance, Clonal anergy and Clonal deletion can be found by doing a search for these terms at google.com .

Questions or comments?
Feel free to cantact me at
camry@torontonian.com
or himmerland2000@yahoo.ca

Regards,
Henry

Re: Solution to Celiac - Oral Tolerance: from on 2004-04-07

Where can I get Oral Tolerance? Is it a pill? Do you take it daily? Do you have any clinical studies that show it helps celiac patients? What are your credentials? Don't mean to not trust, but would sincerely like the answers to these questions so that I can make an informed decision. I have recently been diagnosed with celiac and am having a very hard time adjusting my life to a diet without gluten....my lifestyle is just not that conducive to not eating gluten. If I had a pill that I could take to solve the problem, that would be a miracle for me. Please email me and let me know the answers. Thanks

Re: Solution to Celiac - Oral Tolerance: from on 2004-04-17

br /> My company
Oriel Health Res. has funded the research on celiac disease
using oral tolerance.
PLease understand that research by one group is
different from others. Don't judge Oral tolerance just
because others have reported failures.

There are slight differences in the formula I am using.
For one thing the formula is using peptide prepared
in the homeopathic way.

AS such, the formula is both oral tolerance and homeopathic
remedy and has properties of both

Re: Solution to Celiac - Oral Tolerance: from Emily on 2004-04-24

CD is not mentioned in the Oral Therapy research as far as I can see & it has not been used on humans, either, I understand - so it is of no use to us & the best thing we can do is remain strictly gluten-free.

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...There were several studies demonstrating the effectiveness of orally administered Ag in different animal models of autoimmune diseases, such as experimental allergic encephalomyelitis, collagen induced arthritis, diabetes, but also uveitis, myastenia gravis and transplantation. These mouse or rat models of autoimmune diseases gave the rationale for the therapeutic use of OT in human and this therapeutic approach has been tried in MS and RA, using oral myelin or oral collagen, respectively. In RA, 4 trials of oral type II collagen (CII) in RA have been published. Taken together, these studies suggested that oral CII in RA gave a trend toward clinical improvement, with significance in only 2 studies. Bacterial extract from Escherichia coli containing heat shock proteins has been tried in oral treatment for RA. Two placebo controlled trials and 2 comparative studies gave favorable results for this bacterial extract with no or mild adverse events.

Altough oral / mucosal tolerance has given successful results in animal models of autoimmune diseases, the enthusiasm for this therapeutic approach in human diseases must be tempered. The discrepancies between the effectiveness of OT in animal models and the resullts in human trials raise some questions, the identification of the subgroup of patients who might respond to this treatment and the source (or nature) of the administered Ag (homologous versus heterologous), for instance.

http://www.ingenta.com/isis/searching/ExpandTOC/ingenta?issue=pubinfobike://ben/cdtia/2002/00000001/00000001&index=5