Solution to Celiac - Oral Tolerance: from on 2004-04-06
The source of the problem of Celiac Disease/gluten
intolerance is an overproduction of antibodies to gluten. Generally, celiacs are found to have high blood levels of the antibodies -Immunoglobin A and Immunoglobin G (Ig A & Ig G) to gluten. Some celiacs have low Ig A while
high Ig G is universal to all celiacs/gluten intolerant subjects. Therefore, it is the high Ig G
that needs to be addressed in solving this problem.
Has medical research found a mechanism that actually lowers Ig G which can be applied to autoimmune diseases such as celiac disease? The answer is Yes.
Production of antibodies is controlled by the T cells
which is part of the immune system. The helper T cells
program the immune system to increase antibody production; the suppressor T cell does the opposite
- it lowers production.
The condition or requirement for lowering antibody
levels is having the target antigen accepted by the
suppressor T cell.
This is where Oral Tolerance (O.T.)comes in -
a process that can access the suppressor cell.
In O.T., a peptide(part of protein) having similar antigenic determinants as gliadin(in gluten) is taken orally. Once it is processed by the suppressor T cell, the immune system is set in motion lowering blood levels of specific antibodies and will result
in a cure.
There are 3 activities involved in oral tolerance.
1. Secretion of transfer growth facter-b at the target site. This sends a signal to immune cells to back-off from attacking the small intestine.
2. Clonal Anergy means the immune cells may come within reach of the target organ but will not react.
3. Clonal deletion means the cells that are responsible for antibody production specific to gluten are deleted.
All the above will end autoimmune response and will fix celiac disease.
O.T. has been researched since the 70's and is safe.
Its mechanism has had clinical trials on animals and humans for autoimmune conditions such as uveitis, arthritis, and multiple sclerosis. There are also tests
A better understanding of Oral Tolerance, Clonal anergy and Clonal deletion can be found by doing a search for these terms at google.com .
Questions or comments?
Feel free to cantact me at
Re: Solution to Celiac - Oral Tolerance: from on 2004-04-07
Where can I get Oral Tolerance? Is it a pill? Do you take it daily? Do you have any clinical studies that show it helps celiac patients? What are your credentials? Don't mean to not trust, but would sincerely like the answers to these questions so that I can make an informed decision. I have recently been diagnosed with celiac and am having a very hard time adjusting my life to a diet without gluten....my lifestyle is just not that conducive to not eating gluten. If I had a pill that I could take to solve the problem, that would be a miracle for me. Please email me and let me know the answers. Thanks
Re: Solution to Celiac - Oral Tolerance: from on 2004-04-17
Oriel Health Res. has funded the research on celiac disease
using oral tolerance.
PLease understand that research by one group is
different from others. Don't judge Oral tolerance just
because others have reported failures.
There are slight differences in the formula I am using.
For one thing the formula is using peptide prepared
in the homeopathic way.
AS such, the formula is both oral tolerance and homeopathic
remedy and has properties of both
Re: Solution to Celiac - Oral Tolerance: from Emily on 2004-04-24
CD is not mentioned in the Oral Therapy research as far as I can see & it has not been used on humans, either, I understand - so it is of no use to us & the best thing we can do is remain strictly gluten-free.
...There were several studies demonstrating the effectiveness of orally administered Ag in different animal models of autoimmune diseases, such as experimental allergic encephalomyelitis, collagen induced arthritis, diabetes, but also uveitis, myastenia gravis and transplantation. These mouse or rat models of autoimmune diseases gave the rationale for the therapeutic use of OT in human and this therapeutic approach has been tried in MS and RA, using oral myelin or oral collagen, respectively. In RA, 4 trials of oral type II collagen (CII) in RA have been published. Taken together, these studies suggested that oral CII in RA gave a trend toward clinical improvement, with significance in only 2 studies. Bacterial extract from Escherichia coli containing heat shock proteins has been tried in oral treatment for RA. Two placebo controlled trials and 2 comparative studies gave favorable results for this bacterial extract with no or mild adverse events.
Altough oral / mucosal tolerance has given successful results in animal models of autoimmune diseases, the enthusiasm for this therapeutic approach in human diseases must be tempered. The discrepancies between the effectiveness of OT in animal models and the resullts in human trials raise some questions, the identification of the subgroup of patients who might respond to this treatment and the source (or nature) of the administered Ag (homologous versus heterologous), for instance.
Re: Solution to Celiac - Oral Tolerance: from on 2004-04-24
Oral tolerance has not be much mentioned by researchers
due to failures.
My group which funded the research has had
success which is why I'm posting this article
Re: Solution to Celiac - Oral Tolerance: from on 2004-04-24
I meant Oral tolerance trials on celiac cases has not be much mentioned by researchers
due to failures.
Please do not make negative conclusions just because
others were unsuccessful
Re: Solution to Celiac - Oral Tolerance: from David on 2004-04-27
I think before any individual should consider a new therapeutic treatment for a disorder, that they should be sure to protect their own interests first--namely, their health and their wallet. Oral tolerance has not been successfully used in humans to cure celiac disease, PERIOD. Perhaps the individual making these claims here at this forum would like to share documented proof in a peer-reviewed journal of his successes with oral tolerance "curing" celiac disease. There are many researchers still working out the mechanisms of how celiac disease causes pathology, and working on an alternative cure for the disorder other than a gluten-free diet. And I applaud these efforts, as these scientists welcome peer review, critical input, and--MOST IMPORTANTLY-open scrutiny of their specific techniques and research, which they willingly share. Any person claiming to have a cure, but hiding their credentials, where they are located, where their company is located, and claiming to be the "only one" who possesses something that can cure your disorder, is sadly likely to be someone who is looking to make a quick buck off of your misfortune.
And that isn't medicine or science, it's quackery
Re: Solution to Celiac - Oral Tolerance: from on 2004-04-27
Homeopathy/Oral tolerance fixes celiac
Homeopathy has been used for centuries to alleviate
and even fix a number of ailments.
Homeopathic formulations covers all matter - inorganic and organic.
Homeopathy includes the studies of Isopathy, Nosodes
and Sarcodes. These were the fields where I
made my formulations.
In Isopathy, one uses formula preparations from
what causes the disease (virus, germs, bacteria).
Nosode formulas are from affected parts of illness
while Sarcodes are from organs or tissue
for example preparations using cartilage.
The most popular homeopathic formulas and which most
people are familiar with are those that are diluted
However, my success formulas started with mother
tinctures, which I continue to use.
Now, lately I came upon the topic on "Oral Tolerance",
I realize it has all the factors that make up
mother tincture sarcodes and nosodes.
I am saying that my formulas are both homeopathic solutions and oral tolerance.
If you say that mainstream medicine research has
failed in celiac tests, speak for yourself and
other reseqrch but don't speak
for homeopathic /oral tolerance.
Respect the fact that exact formulas
Re: Solution to Celiac - Oral Tolerance: from David on 2004-04-30
Okay, so if your formula works just provide evidence and the full name, address, and location of your company and store front to purchase your product & proof that you have filed your medical claim of being able to cure a medical illness with your product with the FDA. Otherwise, admit you are just out to make money for yourself