597.Solution to Celiac - Oral Tolerance Moderated discussion and help for gluten free, coeliac, celiac, wheat allergies or intolerance, Cookery and recipes part 2

Re: Solution to Celiac - Oral Tolerance: from on 2004-04-30

br /> The tests are not over yet.
There are no sales yet. But because there are
positive results , I am posting this article.

I'll get to the steps one at a time.

However, if you want proof.
You're a celiac, why don't I give you a sample
of the solution

Re: Solution to Celiac - Oral Tolerance: from David on 2004-05-03

Okay, I can buy into your wish of goodwill to help those members of society with celiac sprue, as I would hope there are some persons out there who do possess true altruism. You speak of having people who have been cured using your method, why not have share their names and experiences here in the forum? Or simply there previous testing showing them to be positively proven to be celiac sufferers by diagnostic testing (ie intestinal biopsies), and then new results showing them to have no damage after your oral tolerance.
Please remember that it is vital that celiacs be very skeptical of supposed cures, as continuing to consume gluten in a celiac patient, even if it is not causing symptoms, has been linked to higher rates of gastrointestinal malignancy (yes that is cancer, folks) and lymphoma (yes, another form of cancer). To simply try "cures" without proof, is to ask another human being to risk their life on your word, which is a great deal to ask of someone on faith alone, especially when one does not know who you are, how to find you, or what your motives are.
Fair enough

Re: Solution to Celiac - Oral Tolerance: from on 2004-05-03

br /> I live at 3704 Venables St.
Burnaby, BC
Canada V5C 2Y8

Tel. (604) 2997940

I cannot give out names of folks who are receiving the formula.
Also, these have not given permission to give any information
out to anyone and I have to respect our agreement.

As I mentioned, oral tolerance is safe.
The formula is a peptide and the system acts towards it
just like it is food - and peptides are segments of protein
which is food.
Also homeopathic preparations are also safe otherwise
folks will beware of them.

Oral tolerance has been researched to lower Immunoglobin G
which is truly high in celiac folks.
That is what the formula is for. Once Ig G to gluten
goes down, then there should be no reaction.

It's not easy tosatisfy what you are asking.
I'll tell you what, there may be one or two who
want to do a blood test for Ig G to gluten after
the test. When that happens, I'll see if they will
agree to communicate with you directly.
This will have to be when the test is finished

Re: Solution to Celiac - Oral Tolerance: from David on 2004-05-05

I must admit I would be very interested in blood testing results in these patients who have responded to the oral tolerance therapy, and would gladly communicate with them directly. I would hope they might consider even sharing their identities and experience in this forum, as others may stumbly upon this forum, and if the therapy works, discover a method that may cure them of celiac disease. They might also discover someone willing to discuss their experiences they have already had with oral tolerance.
When is your testing going to be complete, and when might we expect the published results to be available in a medical journal?
It should be interesting to see how this therapy works, as it has been demonstrated that celiac sprue is a complex immune-mediated disease, which works through tissue-transglutaminase and T-cell, NK cell, and also B-lymphocyte and antibody activity, and not through just IgG, IgA, IgM alone.....especially since some celiac sufferers are completely IgA deficient as far as antibodies go.
Would love to hear exactly what antigenic determinants are used in your formula for oral tolerance, and what they are derived from specifically, but I am guessing I will have to wait for your publication. Dr. Chaitin Khosla at Stanford University in the U.S. is doing some very strong preliminary work in moving ahead with several angles on providing an effective therapy for celiac disease which may permit ingestion of dietary gluten. These efforts include development of an agent that might bind tissue transglutaminase in the bowel, and also of a possible oral enzyme therapy with an acid-stable bacterial peptidase to cleave gliadin into non-toxic fragments upon ingestion. Exciting stuff all around, and especially since the Italians and Australians are continuing to work on tolerance induction through nasal preparations and possible vaccines.
Here is to hoping that all celiac sufferers will soon see the most amazing thing we could hope for this disease--a cure

Re: Solution to Celiac - Oral Tolerance: from on 2004-05-05

br /> I believe the tests to finish within 2 to 3 months, this is an estimate.

I cannot exactly reveal the formula since that would remove
the edge over other research on similar mechanisms.
However, the peptide I use resembles the gliadin of gluten.
It has some differences but enough similarities to be recognized
by a T cell. Oral tolerance generates new cell - suppressor T cells
specific to gliadin. In fact the only requirement to generate
this type of cell is that the formula -peptide be accepted by
a T cell.

You mentioned - tolerance induction through nasal preparations - this
falls under oral tolerance because it works in the same principle
as oral tolerance.

I have to state that I started this project as alternative medicine.
Homeopathy is alternative medicine and when I found this effect
I called it "cell/tissue normalization". It was only later that
I read oral tolerance especially on the internet that I found
it is the same thing. Oral tolerance belongs under mainstream
medicine research.

I shall write on this topic in future but, you understand, it will be under
alternative medicine

Re: Solution to Celiac - Oral Tolerance: from David on 2004-05-11

Well it never hurt an "alternative treatment" method to be described to its would-be participants. What ever happened to the idea of peer-reviewed science, not blind faith in a "secret potion?" Honestly, your inability or unwillingness to give a better description of your methods and product make you and your motives sound very suspect.
And any treatment that is to be consumed by a person, with the claims you are making, is subject to approval by the United States Food and Drug Administration in order for US citizens to be able to take it, unless you do not officially claim any medical capabilities of your product--alternative or mainstream; doesn't matter what words you use to categorize it.
It is not desirable for celiac sufferers to have their hopes raised nor their wallets raided without some specifics on any treatment--since having a disease makes one a sufferer of an illness, not a subject of experiments for profit

Re: Solution to Celiac - Oral Tolerance: from on 2004-05-13

Researchers have recognized a problem in
Oral Tolerance.
The digestive tract's acid environment in the
stomach, alkaline in the small intestine and
enzymes will certainly change proteins and the
peptide formula - rendering it of no medicinal
value. This problem can not be removed by
increasing the dose.

Researchers have tried to bypass the digestive
tract by applying their formula to the nasal
mucous membranes.

Most research you will find on oral tolerance
use just the peptide. However, there were a few
that added a second ingredient which served the
purpose of protecting the antigen/peptide
from the harsh environment of the digestive tract.

I've found two such experiments using liposomes
and microspheres. These experiments can be found
in "Current Topics in Microbiology & Immunology",
Vol. 146 pp. 51-58 and pp. 59-65 respectively.
Their formula consists of the peptide
in tiny solution surrounded by a globe of the
second chemical serving as
a barrier between their remedy and the digestive

HOwever, the two above are impractical since
the liposomes and microspheres are unstable and
within a day or two
the two ingredients separate.

My formula is also that, two ingredients.
The 1st is the peptide similar to
The second is a fixative. It of itself does nothing.

The fixative renders the peptide inert and more
resistant to the harsh environment of the digestive
system. The ideal fixative is an organic substance
containing carbon, hydrogen and oxygen. It is
found in animals, man and in food plants and is

Certainly, some of the peptide may be changed but a fraction will be absorbed
intact and remain active.
I believe, there are other chemicals out there
that may serve the function of protecting the peptide
to keep it active. Our research has simply
found one such chemical which is totally safe.
With all these, the formula is still homeopathic

Re: Solution to Celiac - Oral Tolerance: from s understanding of celiac immunopathogenesis as well. Clearl on 2004-05-17

My background is as a clinical gastroenterologist and immunologist and I have been involved in celiac research for a number of years. I would have to agree with David on many of the points made above.

Much of this so-called oral tolerance/homeopathic remedy disturbs me: Is it FDA approved? What exactly are people asked to ingest? Have you shown the product to be safe? If it is gluten-like, then what will stop it from actually exacerbating coeliac disease? Where are the trials to show it WORKS? ie. that celiacs after "treatment" demonstrate an ability to ingest gluten without symptoms or antibody rise or histologic changes. Has it been compared to placebo? Have you had ethics committee approval for this so-called research?

Currently there is no evidence that a simple oral peptide solution is able to induce tolerance in celiacs, although tolerance induction (almost certainly not via the oral route) will we hope offer a possible treatment in the future.

I have some concerns regarding the and NOT antibody mediated. Antibodies per se are not the CAUSE of villous atrophy, and IgG anti-gliadin Ab is NOT seen in everybody. Treatments will need to address the T cell immunology, not lower the IgG antibody. the mechanisms cited are all recognised ways the immune system may acieve tolerance, but once again, an orally taken peptide has never been shown to do this.

I think the point of this email is to say that any orally taken preparation needs to be thoroughly researched lest it actually worsens the celiac pathology. Further work in this area is always welcome, but grand statements of fixing celiac disease with a simple oral preparation are unwarranted, ungrounded and misleading to the general public

Re: Solution to Celiac - Oral Tolerance: from on 2004-05-18

Please could you send me some important keep feature I must consider when cooking for a celiac

Re: Solution to Celiac - Oral Tolerance: from on 2004-05-19

Hi Holly,

I'm not sure how to answer. How does your question
relate to our formula for celiac/gluten intolerance